Maximultix
Beyond the Dimensions of Analysis
No more one-by-one verification.
As a ready-to-use pre-array sensor chip, it integrates perfectly with the iMSPR-Plex.
Streamline your research and acquire multiple data points simultaneously—all in one injection.
Identical quality. Absolute perfection.
MaxiMultix-ATD analyzes every critical pillar of an antibody’s fate on a single, unified chip. By eliminating the variables found in scattered data, we provide an unparalleled level of integrity and certainty that fragmented analysis simply cannot reach.
The First Innovation
For Antibody Drug Discovery,
Maximultix-ATD Series
A multi-panel solution covering all stages
from structural compatibility to half-life and efficacy.
Now, quickly obtain accurate data
with three dedicated sensor chips optimized
: M-ATD-ProAGL / FcgR23 / FcRn.
Maximultix-ATD Series
1. M-ATD-ProAGL (3-in-One chip)
It simultaneously measures the specific binding characteristics of antibodies to Fc and Fab/Light chain regions with a single injection. Through 3-in-1 fingerprinting analysis for Proteins A, G, and L, we verify antibody isotypes and perform ultra-high-speed primary screening for structural defects or denaturations in just 5 minutes during the initial cell line development (CLD) stage.
2. M-ATD-FcgR23 (6-in-One chip)
It profiles six major FcγR receptors (6-in-1), essential for evaluating the ADCC/ADCP immunological mechanisms of therapeutic antibodies, simultaneously on a single chip. It provides affinity data with high statistical reliability (n=3) without fluid positional deviation.
It simultaneously measure FcRn and HSA(2-in-1), which determine the in vivo half-life and blood persistence. By precisely analyzing pH-dependent binding/dissociation kinetics under pH 6.0 and pH 7.4 conditions
Multi-analysis chip
for verification
of Next-generation
Antibody Drugs,
M-ATD-ProAGL
M-ATD-ProAGL was created to verify the structural integrity of next-generation antibody drugs, such as scFvs, nanobodies, and bispecific antibodies, and to optimize purification processes. Integrating Proteins A, G, and L onto a single chip, experience firsthand unrivaled analytical efficiency in the shortest possible time and at the lowest cost.
M-ATD-ProAGL, Try applying it like this!
1. Verification of 'Structural Completeness' (QC / Discovery)
For next-generation antibodies with structures different from the original antibody, the reaction patterns of Protein A, G, and L spots vary depending on the modified antibody structure. Perfectly verify structural integrity and the presence of fragment impurities on a single chip using Protein A, G, and L binding sensorgrams.
2. Selection of Conditions for Purification Process Optimization
Inject antibody culture medium into the M-ATD-ProAGL chip to monitor the maximum adsorption amount and binding pattern of each Protein A/G/L spot to find the most suitable purification ligand, and find the optimal conditions for efficient antibody elution by stepwise changing the pH conditions of the elution buffer and monitoring the dissociation pattern.
3. Development of Best Cell Lines and Daily Culture Tracking
From the cell line development stage to the main culture, the supernatant is directly injected on a daily basis to determine the optimal harvest time through the increase curve of Max RU of Protein A/G/L, and the risk of protein degradation due to cell death is diagnosed early.
The ADCC / ADCP evaluation
of Antibody drugs and
the simultaneous profiling of Fc gamma receptor variants
M-ATD-FcgR23
Six key Fc gamma receptors essential for the development of therapeutic antibodies have been integrated into a single chip. With just a single continuous injection of serial diluted samples ranging from 100 nM to 5000 nM, a dedicated app precisely analyzes the cross-spots (18 data points in total) of the six receptors (repeated three times) simultaneously.
Realization of 3 replicate analysis of 6 types of Fc gamma receptors on a single chip
Precisely evaluate key FcγRs (CD16a V/F, CD32a H/R, CD16b, CD32b) in the concentration range of 100 nM to 5000 nM to predict antibody-dependent cytotoxicity (ADCC) and antibody-dependent phagocytosis (ADCP), which are the mechanisms of action (MOA) of therapeutic antibodies (mAbs, Fc-fusion proteins, etc.). Based on data obtained from a single concentration series injection, a dedicated analysis app simultaneously processes six receptors to rapidly generate a more precise affinity (KD) dataset.
Precisely evaluate the potential of antibody drug candidates using average affinity results obtained from triplicate data.
For the simultaneous prediction of in vivo half-life of antibody drugs and evaluation of FcRn/HSA binding,
M-ATD-FcRn
It is essential to evaluate the interaction between FcRn and HSA (Human Serum Albumin) to determine the in vivo persistence and pharmacokinetic (PK) characteristics of therapeutic antibodies and Fc fusion proteins.
Realization of multiple analysis of FcRn and HSA linked analysis on a single chip based on pH conditions
To accurately predict the in vivo half-life and pharmacokinetic (PK) profiles of therapeutic antibodies (mAbs, Fc-fusion proteins, etc.), precisely evaluate the key receptors FcRn (Neonatal Fc Receptor) and HSA (Human Serum Albumin) in the concentration range of 156 nM–5000 nM under pH 6.0 and pH 7.4 conditions. Based on data obtained with just a single pH switch and concentration series injection, a dedicated analysis app simultaneously processes binding behaviors to rapidly generate a precise affinity dataset including in vivo recycling mechanisms and the presence of non-specific binding.
Precisely evaluate the potential of antibody drug candidates using average affinity results obtained from triplicate data.
Design Your Own Maximultix.
Your Vision, Tailored by our Technology.
Innovative research demands unprecedented analytical tools.
We bring your original analytical panels to life
on the precision platform of Maximultix.
Bespoke Design
Specify the antigens, antibodies, or proprietary biomarkers you wish to analyze. We will arrange them in the most strategic configuration
on the Maximultix pre-array.
Dedicated Engineering
We go beyond simple manufacturing.
Our analytical experts collaborate closely with you through every step
from chip design to validation to ensure optimal data results.
Your Exclusive Asset
A customized panel optimized solely for your research
will become your most powerful asset in creating differentiated results.