Antibody Therapeutics Scanning & Total Profiling
(iMSPR-PleX & Maximultix)
Minimize in vivo failure risk,
drastically reduce budget and time,
and obtain richer and more accurate data!
Next-Generation Antibody Multi-spot CRO Service
"Complete complex antibody evaluations most efficiently with Smart 2-Stage!"
[Stage 1] Quick Screening
Sensor chip: MMx-ATD-ProAGL
Sample: 50 nM Antibody, 100 nM Target Protein
Objective: Structural equivalence to the original and presence or absence of target binding
[Items & Details]
Items
What is evaluated?
Why is it necessary?
1. Confirm struct.
Scanning Protein A/G (Fc) and Protein L (Kappa) reactivity
Prevents false positives caused by denatured/defective antibodies
2. Target Binding
Confirming binding (Binding On/Off) after injecting the Target Antigen onto the antibody
Prevents 100% waste of unnecessary in-depth analysis budget by pre-screening
[Analysis fee (VAT ex)]
Analysis fee
70,000 KRW / Ab
Discounts applied based on the number of analyses
MMx-ATD-ProAGL
790,000 KRW / chip
Pre-made sensor chip with Proteins A, G, and L
Report
349,000 KRW / Report
Protein A, G, L Binding Data
Rmax / Single-concentration KD
Target binding Yes/No, SC based KD
[Stage 2] Quantitative & Functional Profiling (Optional)
Sensor chip: MMx-ATD-ProAGL / FcgR2/3 and FcRn
Sample (Abs): 156 to 5000 nM
Target: 3.1 to 100 nM
CD64: 3.1 to 100 nM
Objective: Accurate affinity and kinetics values, precise prediction of in-vivo half-life
[Items, Price and Details]
Items & Price
What is evaluated?
Why is it necessary?
1. Target Kinetics
350,000 KRW / Ab
MMx-ATD-ProAGL
1:1 Single Cycle Kinetic Fitting (Kon, Koff, Precision KD) via Multi-concentration Target Antigen Injection
Calculation accurate target affinity data for best-in-class selection
2. CD64 Kinetics
450,000 KRW / Ab
MMx-ATD-ProAGL
1:1 Single Cycle Kinetic Fitting (Kon, Koff, Precision KD) via Multi-concentration Target Antigen Injection
Completely proven the structural normal function and basal immune function efficacy of the Fc region
3. FcRn tests
350,000 KRW / Ab
590,000 KRW / chip
; MMx-ATD-FcRn
Evaluation of pH 6.0 (endosome binding) & pH 7.4 (blood dissociation)
Pre-verification of in vivo half-life
4. FcgR II / III tests
990,000 KRW / Ab
; 165,000 / KD
590,000 KRW / chip
; MMx-ATD-FcgR2/3
Analysis of simultaneous responses of 6 types of FcγR receptor
Prediction of ADCC/ADCP immunocytotoxicity efficacy
[Add on] Epitope Binning (Optional)
Sensor chip: C-Dex100
Maximum: 50 Abs
Abs (Immobilization): 100 ~ 200 ug/ml 10ul
Target: 100 nM
Abs (binding): 100 nM
Method: Sandwich or Pre-mix
Objective: Classification of antibody binding epitope overlap, selection of optimal pairs for bispecific antibodies and ADC/Sandwich ELISA
[Items & Details]
Items
What is evaluated?
Why is it necessary?
1. Pairwise Epitope Binning
Measurement of the sandwiching or competitive inhibition patterns
Clearly map and group independent antibody sets (Bin Sets) that recognize different epitopes
2. Bispecific & Pair Selection
Selection of optimal match pair antibody combinations for bispecific antibody (BsAb) development and sandwich assays
Verification of novel epitopes and configuration of dual-antibody/diagnostic modules for IP protection
[Analysis fee (VAT ex)]
Abs Array chip
15,000 KRW / Ab
Fabrication of antibody array chips
C-Dex100
220,000 KRW / chip
Chip for protein array
Analysis fee
80,000 KRW / Ab
Report
349,000 KRW / Report